Rhia Ventures

At the foundation of each of our investments is a commitment to helping our portfolio companies grow so they can better serve employers of all size. Employers make significant investments to make health care more accessible and easier to navigate. Our portfolio companies bring innovations to market that meet some of employers’ most pressing health care needs, including care navigation, advanced primary care, fertility planning and advanced analytics. Here are some of our current key areas of focus: Drug Management: Prices for drugs – particularly in high-cost categories like oncology, obesity and cell gene therapy – are outpacing inflation. We seek investment opportunities that address drug spend and access, with a specific focus on high-cost drugs or conditions that are highly prevalent in employer-sponsored insurance populations. Data and Analytics: Employers need solutions that make the vast amount of available health care data actionable and tailored to their insured populations. As such, we consider investment opportunities that provide the necessary infrastructure and analytic capabilities to impact administrative efficiency or drive improvements in health care quality and price transparency. Small- and Medium-Sized Business (SMB) Solutions: Rising health care costs place a severe burden on SMBs. In fact, the smallest employers are facing the biggest hikes in premium costs. Employers with just 1-10 employees saw a 12% increase in average family plan premiums in 2022. To help navigate this challenge, we weigh investment opportunities that enable SMBs to provide more affordable, high-quality, and equitable health care to employees through new purchasing and coverage models. Behavioral Health: Fragmented solutions have proven ineffective in addressing the behavioral health needs of patients. To help drive change in this area, we’re considering investment opportunities that approach patient care holistically, with behavioral and medical spend linked to create a comprehensive and unified view of the patient. Women’s Health: Despite deep investments in this area from employers, too many gaps in health and access to care still exist. There are opportunities to solve for the discrete, largely unmet, needs of women in the workforce, including but not limited to maternity, menopause, and comprehensive women’s primary care.

We believe women drive outsize investments returns. Ingeborg focuses on direct investments into women-led, early-stage startups. We invest in the full female experience: we value innovation that empowers and improves motherhood, career, financial security, women’s health and better living. We are female-consumer centric and business-model agnostic in our direct investment approach. Our core strategy is complimented by select investments into later stage startups and women-led venture or private-equity funds. Why Women?Savvy Investors: 69% top-quartile VC funds include women decision makers Capital-Efficient Founders: 2.5x revenue generated vs. men Dominant Consumers: 85% consumer purchasing power Why Now?Under-Funded: 13% decision makers at U.S. VC funds are women Under-Valued: 2% VC dollars in the U.S. go to all-female founder teams Under-Estimated: 10% Fortune 500 CEOs are women

Cross-Border Impact Ventures is an impact venture capital firm on a mission to revolutionize venture capital investing in health technology. We work with visionary teams to leapfrog access to world leading affordable technologies for women, children and adolescents. Health technologies are more scalable than ever before. The time is now to take a global tailored approach in this sector. OUR INVESTMENT UNIVERSE We look for audacious companies commercializing globally relevant medical devices, diagnostics, therapeutics and digital health innovations that are prioritizing huge market opportunities in women, children and adolescent health. We value real world and clinical data. We focus on 4 key sectors: Sexual and reproductive health, Maternal, newborn and child health, General health, including chronic diseases, and Health software infrastructure. We invest in companies addressing gender health inequalities. Positive impact and financial returns are not mutually exclusive. We seek opportunities that offer both high impact & high returns. OUR IMPACT We believe good health is a right that should not be restricted by gender, age, race, wealth and borders. We hold ourselves to the highest standard of impact investing and implement recognized impact management processes. We invest with a gender and diversity lens. WE ARE ENABLERS We are specialists in women, children and adolescent health with deep expertise in health technology. We are hands-on investors and support our exceptional management teams with access to new markets, unique forms of capital and health technology expertIse in North America, Europe as well as global markets. WE UNLOCK GLOBAL IMPACT OPPORTUNITIES Cutting edge technologies take decades to reach underserved communities. We work with management teams to fast track the process.

We build and invest in companies that positively impact human health with smart solutions, breakthrough science and technology. Our focus is on innovation in digital healthcare, connected medical devices, and life sciences We focus on therapeutic and preventive technology solutions addressing unmet needs in some of the most vulnerable segments of society: women, children and the elderly. Digital transformation will continue to shape our lives and has the potential to transform care. We aim to build and support Digital Health & Life Sciences companies working to make healthcare smarter, using data to improve care and outcomes, and reinventing the patient journey. Our vision for the future of healthcare guides our investment strategy. A data driven digital transformation will shape the future of healthcare. The traditional biopharma model will evolve into an integrated model, where prevention, precision cure, and care management will coexist in a highly personalized patient-centric solution. Our goal is to support the creation of life transforming care products and therapies. We believe the future of healthcare lies in supporting the next-generation of founders and teams who will lead us there. What do we look for?Innovation and groundbreaking opportunities in our sectors of focus: digital health, life sciences, tech-enabled care delivery, and connected devices Innovative treatments for Central Nervous System (CNS) disorders, in particular neurodevelopmental disorders, mental health and epilepsy Founders and teams with domain expertise who seek collaborative investment partners Investments that span development and commercial phases, with a focus on early stage opportunities (Pre-Seed to Series A). Our investment approachOur investment approach combines direct investments in early-stage companies with venture creation from bold ideas in global innovation hubs Our goal is to enable talented entrepreneurs to scale more quickly and effectively through access to our capital, enterprise capabilities and consumer touchpoints, while offering expertise and insights from Angelini’s unique perspective. We invest primarily across Europe, North America and Israel, recognizing that healthcare technology innovation is occurring in many cities around the world. We have committed €300M for investments and company creation in digital health and life sciences. What do we commit to you?Active and involved healthcare investors who operate with integrity, approachability, and transparency A team of passionate healthcare and venture capital experts diverse in demographic and experience A track record of success and experience navigating the ups and downs of early-stage company building Access to a world-class advisory board to leverage C-level experience, expertise, and leadership in healthcare

As part of our investment approach, we developed a structured evaluation process, the “FemHealth Framework.” The first element (re)imagines women’s health as conditions appearing only in women, mostly in women, and differently in women. This concept from the FemHealth Framework (© 2019 FemHealth Ventures) was first published in 2019 and is increasingly thought of as a new lens through which to view women’s health. At FemHealth Ventures, we are excited about the increasing adoption of this broader definition of women’s health and the exciting new treatments it will engender. Only in Women Some conditions appear only in women. Examples include: endometriosis polycystic ovarian syndrome cervical cancer Mostly in Women Some conditions appear mostly in women. Examples include: breast cancer lupus multiple sclerosis Differently in Women Some conditions appear differently in women. Examples include: heart disease diabetes asthma Every cell has a sex A universe of possibilities is opened in women’s health when we start with the most basic building block: our cells. Each of the 30 trillion cells in a woman’s body has a different chromosomal makeup than a man. For example, a skin cell from a woman will have XX chromosomes, but a skin cell from a man will have XY chromosomes. This difference between women and men holds true throughout every single cell in the body. As a result, even the same disease can present differently in women versus men and require distinct treatment paradigms. Women’s health is more than “bikini medicine.” The term “bikini medicine” generally refers to conditions treated by obstetricians or gynecologists. We’ve (re)imagined women’s health as a broad spectrum of conditions that can impact the whole body, ranging from ovarian cancer, to autoimmune disease, to cardiovascular disease, and everything in between. A multitude of possibilities for innovation in women’s health exist. And we are here to help bring them to life.

From startups to more experienced companies, we offer investment capital joined with the expertise of an integrated health system and health plan. We actively partner with organizations to support their success and positively impact the communities we serve. We also actively partner with other like-minded health care organizations and strategic investors to collectively share expertise and drive scale. By leveraging our venture network, we will drive growth and value for portfolio companies while changing the future of health care. What we invest in:Companies and solutions aligned with our vision and strategic priorities Experienced, in-place management teams Well-developed, unique value propositions and business models Existing customers and revenue stream of $1M or more Solutions that amplify our clinical and operational expertise What we do not invest in:Class III medical devices Pharmaceuticals or biotech Pre-revenue companies* Solutions outside our mission, vision and values Other ways we work with emerging innovation companies to create value:Pool resources De-risk commercialization Collaboration agreements