Cross-Border Impact Ventures

We build and invest in companies that positively impact human health with smart solutions, breakthrough science and technology. Our focus is on innovation in digital healthcare, connected medical devices, and life sciences We focus on therapeutic and preventive technology solutions addressing unmet needs in some of the most vulnerable segments of society: women, children and the elderly. Digital transformation will continue to shape our lives and has the potential to transform care. We aim to build and support Digital Health & Life Sciences companies working to make healthcare smarter, using data to improve care and outcomes, and reinventing the patient journey. Our vision for the future of healthcare guides our investment strategy. A data driven digital transformation will shape the future of healthcare. The traditional biopharma model will evolve into an integrated model, where prevention, precision cure, and care management will coexist in a highly personalized patient-centric solution. Our goal is to support the creation of life transforming care products and therapies. We believe the future of healthcare lies in supporting the next-generation of founders and teams who will lead us there. What do we look for?Innovation and groundbreaking opportunities in our sectors of focus: digital health, life sciences, tech-enabled care delivery, and connected devices Innovative treatments for Central Nervous System (CNS) disorders, in particular neurodevelopmental disorders, mental health and epilepsy Founders and teams with domain expertise who seek collaborative investment partners Investments that span development and commercial phases, with a focus on early stage opportunities (Pre-Seed to Series A). Our investment approachOur investment approach combines direct investments in early-stage companies with venture creation from bold ideas in global innovation hubs Our goal is to enable talented entrepreneurs to scale more quickly and effectively through access to our capital, enterprise capabilities and consumer touchpoints, while offering expertise and insights from Angelini’s unique perspective. We invest primarily across Europe, North America and Israel, recognizing that healthcare technology innovation is occurring in many cities around the world. We have committed €300M for investments and company creation in digital health and life sciences. What do we commit to you?Active and involved healthcare investors who operate with integrity, approachability, and transparency A team of passionate healthcare and venture capital experts diverse in demographic and experience A track record of success and experience navigating the ups and downs of early-stage company building Access to a world-class advisory board to leverage C-level experience, expertise, and leadership in healthcare

As part of our investment approach, we developed a structured evaluation process, the “FemHealth Framework.” The first element (re)imagines women’s health as conditions appearing only in women, mostly in women, and differently in women. This concept from the FemHealth Framework (© 2019 FemHealth Ventures) was first published in 2019 and is increasingly thought of as a new lens through which to view women’s health. At FemHealth Ventures, we are excited about the increasing adoption of this broader definition of women’s health and the exciting new treatments it will engender. Only in Women Some conditions appear only in women. Examples include: endometriosis polycystic ovarian syndrome cervical cancer Mostly in Women Some conditions appear mostly in women. Examples include: breast cancer lupus multiple sclerosis Differently in Women Some conditions appear differently in women. Examples include: heart disease diabetes asthma Every cell has a sex A universe of possibilities is opened in women’s health when we start with the most basic building block: our cells. Each of the 30 trillion cells in a woman’s body has a different chromosomal makeup than a man. For example, a skin cell from a woman will have XX chromosomes, but a skin cell from a man will have XY chromosomes. This difference between women and men holds true throughout every single cell in the body. As a result, even the same disease can present differently in women versus men and require distinct treatment paradigms. Women’s health is more than “bikini medicine.” The term “bikini medicine” generally refers to conditions treated by obstetricians or gynecologists. We’ve (re)imagined women’s health as a broad spectrum of conditions that can impact the whole body, ranging from ovarian cancer, to autoimmune disease, to cardiovascular disease, and everything in between. A multitude of possibilities for innovation in women’s health exist. And we are here to help bring them to life.

Our strategy leverages an extensive hospital system and health plan network of relationships to target attractive market segments, to identify and evaluate investment opportunities, and to support the growth of our portfolio companies. Current Areas of Focus:Administrative Automation Behavioral Health: HCIT & Services Data Security Digital Therapeutics Genomics: Applications & Analytics Patient Safety & Risk Monitoring Pharma Data & Analytics Platforms Social Determinants of Health Virtual Care Models Women’s Health: HCIT & Services

We see enormous opportunity in historically overlooked market segments, and we leverage our unique expertise to translate these opportunities into social and financial returns for our investors. Adjuvant’s investment model is heavily influenced by global trends such as climate change, the empowerment of women and girls, urbanization, antimicrobial resistance, and globalization. These trends guide us toward looming public health threats and the high impact innovations that will address them. Built to Improve Health, for Everyone Our mission is simple: invest in the most promising public health technologies and ensure they are made accessible to those who need them most. We invest in innovative technologies to address high-burden and neglected infectious diseases, maternal and child health, and reproductive and sexual health. Within the infectious disease category, we focus on the "big three" (HIV/AIDS, tuberculosis, malaria), tropical diseases like schistosomiasis and onchocerciasis, pandemic threats such as Middle East Respiratory Syndrome (MERS) and Lassa fever, and anti-microbial resistance (AMR). The majority of our investment activity is built upon commercializing technologies that have demonstrated safety and efficacy in humans, with the goal of accelerating the global availability of the most impactful medical innovations. Investing in a Changing World Healthcare spending in emerging economies is one of the fastest growing sectors in the world. Global economic growth is moving billions of people into the middle class, while the call for universal health equity is driving more resources than ever to healthcare for low-income populations. Despite these trends, life sciences investment in this large and growing segment is remarkably low. Our unique focus targets innovations poised to deliver unprecedented health outcomes in underserved markets with the goal of generating truly differentiated "double-bottom-line" returns for our investors. A Global Network of Investors Working to Build a Healthier Future Adjuvant is backed by leading strategic investors and alternative asset managers who understand the global public health landscape, providing invaluable domain expertise and support on top of their capital commitments.

Rhia Ventures’ mission is to create a vibrant US market for sexual, reproductive, and maternal health that produces equitable outcomes for all. This multi-billion dollar market has tremendous potential for public health impact, but it has been built on flawed systems that perpetuate unjust outcomes for women of color, low-income women, and others directly affected by systemic inequities. Our work is to transform this market. We know that transformation happens when partners with long experience in reproductive health and justice come together with market-facing actors to create deep, meaningful impact. By connecting activists, public health professionals, scientists, entrepreneurs, corporates, and investors, together we will build a more just marketplace. Rhia is enabling this change through four complementary efforts: We make direct investments in early- and growth-stage companies that are driving innovation, access, and equity in reproductive and maternal health, through our wholly owned venture fund, RH Capital Corporation. We provide technical assistance and shared resources to these companies and others so that they can strengthen their work in health equity and spur change across the venture ecosystem. We work through our Corporate Engagement and Blossom programs to change social norms, practices, and people that influence this market. We produce a systems-change assessment of the market, identifying the key leverage points for addressing systemic racism and other inequities to inform Rhia’s programs and share with grant-makers, investors, and policy-makers seeking to “make this market work for justice,” to paraphrase Darren Walker of the Ford Foundation. Our Vision for Success Alongside our partners, our efforts will: Catalyze investment in innovation that improves equity, access, and outcomes in reproductive and maternal health care Transform systems in the reproductive and maternal health market, to redress systemic inequity and contributes to improving reproductive and maternal health outcomes for women of color, low-income women, and others directly affected by systemic inequities Amplify the perspectives and work of stakeholders of color Strengthen social norms, to support high-quality maternal and reproductive health care for all women and birthing people in the US

At Town Hall Ventures, we seek to partner with entrepreneurs who are as passionate as we are about changing our health care system. When we invest, we will make a substantial commitment of our time, network and resources to support entrepreneurs and their investors through the ups and downs of building successful companies. It’s why we choose to invest in fewer opportunities than most and only in the most impactful - focusing all of our energy working side-by-side with our partners to create and scale the breakthrough companies that will transform health care. Our Mission Using innovation to fix health inequities. Those fortunate enough to be born in the right zip code live longer and healthier lives than those in communities next door. Systemically, people who represent diverse racial, ethnic and gender identities, especially when combined with lower socioeconomic status, experience substantially worse health outcomes in the United States. These inequities in health - physical, mental and social determinants - result in individual, community and national struggles. When we provide great health care to the least fortunate, we are benefiting our entire societal fabric. We have an opportunity to shift investment away from nice-to-have ideas to proven solutions that improve care for populations that have long been underserved. Innovations aimed at improving care have been slow to come to areas that need it most, including: primary care, mental health, addiction, end-of-life care, kidney care, maternity and newborn health. The costs of ignoring these issues are carried by everyone. Enter the mission-driven entrepreneur. Over the past few years, innovative health care delivery approaches that serve Medicare populations have begun to emerge. Entrepreneurs have brought a new focus on reinvigorating primary care and pushing care into more comfortable settings. These models are just getting started, touching only 2% of the Medicare population today, but have tremendous potential to transform health for millions more. Thanks to an improved set of incentives, similar innovation is now coming to Medicaid. Entrepreneurs are beginning to focus on the needs of this population with the goal of dramatically improving health outcomes for patients and providing value to the hospitals, managed care plans, and State and Federal governments who care for them. Companies who create effective solutions to these challenges have the opportunity to improve the lives of 120 million Americans.