Title: Senior Scientist / Principal Scientist, Bioprocess Sciences

Location: San Diego

Job Type: Full-Time

About Us: A stealth-mode biotech focused on developing best-in-class delivery for in vivo gene editing.

Job Summary: We are seeking a highly motivated and experienced scientific expert to join our team as a Senior Scientist or Principal Scientist of Bioprocess Sciences. This role will provide technical expertise for bacterial protein production programs supporting research and development. The successful candidate will be part of a dynamic team of scientists responsible for process development, scale-up strategy and external manufacturing oversight. Title and compensation will be commensurate with experience.

Key Responsibilities:

Provide technical expertise for bacterial strain engineering, fermentation, protein expression, purification, and protein characterization activities.
Develop, optimize, and scale bacterial culture and purification processes for internal and external manufacturing.
Manage and oversee activities at contract development and manufacturing organizations (CDMOs), including tech transfer, process troubleshooting, timelines, and deliverables.
Partner cross-functionally with research, analytical, quality, and leadership teams to achieve project milestones.
Establish and maintain robust documentation, protocols, and data packages to support internal decision-making and external partners.
Prepare and present technical reports, development strategies, and risk assessments to internal stakeholders.
Stay current with advancements in bioprocessing technologies, manufacturing trends, and regulatory expectations.

Qualifications:

D. degree in Chemistry, Biology, Biochemistry, Biomedical Engineering, Chemical Engineering, or a related field.
6+ years of progressive experience in bacterial protein expression, purification, and bioprocess development.
Demonstrated experience leading projects and mentoring or managing scientists.
Hands-on expertise with affinity-based protein purification (e.g., FPLC), bacterial expression systems, and routine molecular biology assays.
Strong working knowledge of SDS-PAGE, Western blotting, ELISA, and other biochemical and biophysical assays.
Experience interpreting QC assays (fluorometric, chromogenic, etc.) and assessing data quality and process performance.
Routine use of electronic laboratory notebooks (e.g., Benchling) with a strong commitment to data integrity.
Excellent analytical, communication, and organizational skills with the ability to manage multiple priorities.
Ability to work independently in a fast-paced, evolving environment.

Preferred Qualifications:

Direct experience managing or collaborating with CDMOs for process development or manufacturing.
Experience with bioreactor operations, scale-up, and tech transfer.
Protein characterization experience using HPLC/UPLC and/or LC-MS.
Familiarity with regulatory expectations related to bioprocessing and manufacturing.
Background in protein engineering or recombinant protein production.

Benefits:

Competitive salary, equity, and comprehensive benefits package.
Opportunities for professional growth and leadership development.
Fast-paced, collaborative, and innovative work environment.

How to Apply: Interested candidates should submit their resume and a cover letter detailing relevant experience. To be considered for the role, applicants must be:

Eligible to work in the United States for any employer without sponsorship.
Able to work onsite in the lab located in San Diego.
A direct candidate and not from a third party, i.e., staffing agency.

Salary: $120,000-$190,000 Salary Range

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Senior Scientist / Principal Scientist, Bioprocess Sciences