Vsquared Ventures

We invest in early-stage R&D-focused individuals and teams solving complex technical challenges with large potential for commercial application. INVESTMENT AREAS We like to invest in teams building solutions in these technical domains: Software++AI & ML Big Data AR, VR & XR Cybersecurity Cloud/DevSecOps Distributed systems Performance computing Life SciencePersonalized medicine Drug discovery software Precision medicine Biofabrication Digital twins Organoids other BioTech, MedTech HardwareRobotics Automation IoT Industry 4.0 Nanotechnology Material Science Space

2048 Ventures is a thesis-driven earliest stage venture capital firm. We are founders, experienced operators, nerds and dreamers obsessed with the future. We've backed over 200 startups and have the experience and conviction to lead your pre-seed. We get you and your vision before others We are systems thinkers, engineers, and product junkies. We think about the future non-stop and are ready to understand and back you before anyone else. When we decide to invest, we write you a check and then help you close the rest of the round. If you are a mission-driven team, with strong founder market-fit and a vision for what the future should look like, then we would love to meet you. We love serial founders, but we are also very excited about being the first to believe in underdogs, immigrants, and diverse founders who are going on their first founder journey. We are not your typical pre-seed firm We are a thesis-driven investor and invest in next generation platforms - APIs, data, infrastructure, marketplaces, and specific types of vertical SaaS. We invest across verticals, but spend most of our time thinking about: biotechnology, digital health, AI/ML, Robotics, AR/VR, Blockchain, Security, Energy, Mobility, Logistics, Fintech, Marketplaces, Productivity, Culture, and Communities. We don't care where you are based and we are happy to lead your pre-seed anywhere in North America. We've invested across 20+ cities including NYC, LA, Boston, Toronto, Austin, Denver, Seattle, Montreal, Atlanta, Detroit, Chicago, Philadelphia, and Minneapolis. Who we are We are a team of experienced operators and dreamers who are passionate about working with founders at the earliest stage. Collectively, we have invested in over 200 early stage startups. We are proud to have an NPS score of 100 from our founders.

We are in the midst of technological shifts at a pace faster than ever before. Calculus VC capitalizes on these shifts to deliver returns and impact. We invest in the Series A and Series B stages of startups in the below sectors: FUTURE OF COMPUTING AND AI Continued advancements in AI will demand new developments in hardware and software. New computing materials and interfaces may emerge. Computing power may be more distributed, and the world will be infinitely more connected. These and more, are our areas of interest: Intelligence beyond language: We expect AI to understand quantitative models and physical phenomenon just as well as it understands language. Large Quantitiative Models are a focus for us. New hardware, materials, and architectures: We expect that demand for computing power will grow exponentially. Quantum computing, as well as distributed computing are expected to grow. We expect advancements in computing materials beyond silicon. Immersive and neural interfaces: These interfaces already exist, we expect they will become more mainstream. Spatial computing, integrating the physical world with digital environments may be our future. COMPUTATIONAL LIFE SCIENCES AND HEALTHTECH Breakthroughs in biology, materials, sensors, and data science are converging to redefine healthcare. Precision and personalization will take center stage as AI enhances how we detect, monitor, and treat disease. Areas of interest include: AI-First Therapeutics and Discovery Platforms: ML-powered platforms designing drugs and biologics via simulation, predictive modeling, and data-rich experimentation. Infrastructure for Programmable Biology: Tools that make biology engineerable – lab automation, bioinformatics, 3D bioprinting, next-gen diagnostics and R&D devices. Continuous, Data-Driven and Personalized Care: Wearables, medical devices, and diagnostics to deliver patient-centric care. These models turn users into real-time data streams, enabling adaptive treatment and personalized interventions. ADVANCED INDUSTRIAL TECHNOLOGIES As we expand the frontiers of possibility, we expect industry to evolve with intelligence, autonomy and environmental sustainability at its core. Areas of focus include: AI and automation in industry: Intelligent machines will optimize production, reduce waste, and enable new workflows. From predictive maintenance to robotic manufacturing, automation will power the next industrial revolution. We support startups enabling this vision. Land, ocean, and space transport and communications: We are interested in advanced materials, robotics, sensors, systems and software that will unlock new frontiers from deep-sea mapping to planetary missions. Resource efficiency: Building the future will demand large reserves of energy and natural resources. Technologies that can serve our energy, food, water, and agricultural needs while supporting a better planet are of interest to us.

At Menlo Ventures, we go ALL IN. This isn’t just a motto, but how we show up everyday for the companies we back, the investors who back us, and each other. When we win, we win as a team. 47 Years 80+ Public Companies 165 + Mergers + Aquisitions $5B+ Under Management We focus on the "three stages of early" We are investors and company builders - we know what it takes to turn a budding idea into a scalable business. We work with early-stage founders to find product-market fit, develop go-to-market strategies, scale their organizations, and support them as they grow. Inception: Our Menlo Labs team helps founders validate early-stage ideas, de-risk opportunities, and build successful foundations. Venture: Our venture team provides series A and B startups with guidance and hands-on help as they build their teams and products. Inflection: Our inflection team supports early growth-stage startups during critical points as they prepare to scale. Our focus areas At every stage from inception through IPO, we invest in game-changing ideas that reinvent life and work. Although we remain open to new ventures within consumer, enterprise, and healthcare, we go deep in the following seven focus areas: AI: Generative AI is breaking into every software vertical, and winners in these markets will create massive economic and societal value. Menlo Ventures is placing bets on the most promising GenAI companies at the infrastructure and application layers, where we see immense potential for groundbreaking businesses that will reshape industries and push the boundaries of what we can achieve. Bio + Healthcare: Innovations at the intersection of advancements in technology and biology will drive major improvements in the quality of our health and the cost of healthcare. At Menlo, we invest at that intersection - backing breakthrough digital health companies (vertical SaaS and digital care) and novel life sciences companies (therapeutic platforms and transformative technologies). Consumer: The world we live in today is enhanced by technologies we might not have thought possible even 10 years ago. There is so much still to come. At Menlo, we invest in the game-changing companies of the future, those that will help us do things better, faster, or cheaper than we can today. Cloud Infrastructure: As enterprises continue migrating to the public cloud, a new generation of companies will write the playbook for the underlying infrastructure that powers their applications. These tools and platforms are built for and cater to the developer, optimized for time-to-integration with beautiful, easy-to-use UIs and APIs. Cybersecurity: In a complex, post-pandemic world, rapid cloud adoption and the proliferation of open-source software have dramatically expanded the attack surface for bad actors against enterprises, governments, and their applications. Additionally, the shift-left approach to software development requires developers to embrace a security-first mindset. As the cyber war continues, Menlo will back the best teams fighting on the frontlines. Fintech: Financial transactions and services power the global economy. Menlo invests in four fintech categories: dev-focused infrastructure and embedded finance (API layers), vertical banking, end-to-end financial services for consumers and SMBs, and tools that serve finance teams and the office of the CFO. SaaS: The shift to the cloud introduced an entirely new business model–Software-as-a-Service–and created unprecedented opportunities for enterprise software companies. Menlo divides the SaaS landscape into three categories, each with a distinct point of view that guides our investment, research, and resources: Departmental SaaS, Vertical SaaS, and Horizontal SaaS. Supply Chain + Automation: This once-in-a-generation reinvention/reinvigoration of the supply chain will create a world that is more efficient, resilient, and sustainable because of the operational efficiencies we gain. With an eye on a more functional future, Menlo invests in a broad range of technologies–robotics and industrial automation among them.

Navigare Ventures is an early-stage investor specialized in science-driven companies. Through our investments, we strengthen the industrial and societal impact of research, as well as the long-term financial capacity of our owners, Wallenberg Investments AB. Our core investment themes within deep tech are underpinned by our knowledge and network in a number of scientific fields and industries. These include advanced computing and quantum technologies, synthetic biology and bio innovation, advanced materials and nano technology as well as data-driven life science. We are long term investors - Seed and Series A and beyond - and form deep and lasting partnerships with founders and entrepreneurs. Our extensive industrial and scientific networks gives us the opportunity to provide capital, network, and know-how to transform promising science start-ups into successful companies. Who we are Navigare Ventures, based in Stockholm, is a fully owned subsidiary of Wallenberg Investments AB. We are a team of scientists, industrialists and entrepreneurs who understand the challenges of turning cutting-edge technologies to successful ventures. As part of the Wallenberg ecosystem, our returns fuel the next generation of scientific advancement through research funding from the Wallenberg Foundations to Swedish universities. What we are looking for We partner with experienced entrepreneurial teams that combine scientific excellence with strong business acumen. In this respect, your company should have a unique offering based on a profound understanding of your scientific or technological field and its market and industrial environment. You should also be capable of demonstrating the viability and commercial potential of your product by engaging with real customers. You are raising capital to scale the R&D, production, marketing, and sales capabilities of your company. Our investment philosophy We only invest in companies we understand. While this is an important general principle in any investment activity, it is even more important when making early-stage investments in new technology. If we don’t understand your science, we won’t understand what experts tell us about the value chain and how it works, or what the competitive landscape looks like. And most importantly, we won’t be able to help you develop your strategy and navigate through the challenges of deep-tech start-ups. So, when preparing a meeting with us, don’t put too much emphasis on future revenue projections. That’s important too, in due time. But first, be prepared for long sessions in front of a whiteboard, explaining to us how your material, algorithm, or antibody functions. We don’t need to understand all the equations, but we need to get the heuristics. We are scientists at heart, eager to learn, and we carry a deep conviction that the world is fundamentally understandable. Core investment themesAdvanced computing and quantum technologies: Digitization and automation deepens in industry and society, driven by breakthroughs in computing and AI. Our focus includes improving existing technologies as well as finding completely new platforms in AI and other areas of applied mathematics as well as in novel computer architectures, communication technology, hardware and design. Synthetic biology and bio innovation: Synthetic biology and bio innovations contribute to a more sustainable society. Companies in this field often combine principles of biology, engineering, and computer science for the development of new biological products and manufacturing methods. Advanced materials and nano technology: New materials and nanoscale technology enable disruptions with the potential to benefit numerous existing industries. From quantum materials to biomaterials and biologically inspired nanostructures, we look for the most promising technology platforms in the field. Data-driven life science: Combining digital technology and data with life science drives scientific understanding and enables novel products. Our focus is on data-driven methods to increase personalization and precision of medical interventions, accelerate product development, digitalize care among other advancements.

Lingotto’s Innovation Fund is a new $600mm+ AUM crossover (public & private) fund focused on making concentrated and long-term investments in companies operating at the cutting edge of technological and business-model innovation. Core to our investment thesis is the fact that market returns are dominated by extreme structural winners – we seek to identify decades-long secular trends and the management teams best positioned to capitalize on them in the early years. The senior team has a notable history of private investments including: OpenAI, SpaceX, Alibaba, Coupang, Stripe, Databricks, Spotify, Airbnb, Tempus, Recursion, Ginkgo Bioworks, Palantir, Epic Games, Joby Aviation, Indigo, Aira, Humane, H2 Green Steel. The Innovation Fund is co-managed by James Anderson (CIO & Managing Partner) and Morgan Samet (Co-Head & Managing Partner). James has over 40 years of investment experience – most recently as a Partner at Baillie Gifford, where he managed over £100bn in AUM throughout his tenure. As head of the firm’s flagship fund, the Scottish Mortgage Investment Trust, he delivered a +1,555% return vs. +354% for the FTSE all-world benchmark (between April 2000 and March 2022). He was instrumental in the firm’s move into private investing starting with Alibaba in 2012. Morgan has over 19 years of experience in private and public market investing. She has previously worked at Belfer Management, Pzena Investment Management, Thomas H. Lee Partners, and Goldman Sachs. She received her MBA from Harvard Business School. The Innovation Fund is a part of Lingotto, a $4.5bn+ investment management company supported with permanent capital from Exor and additional external LPs. Exor is one of Europe’s largest publicly traded holding companies. Its assets include companies like Stellantis (Fiat, Chrysler, Citroen), Ferrari, Philips, Juventus Football Club, the Economist and Christian Louboutin. Exor’s CEO is John Elkann (Chairman of Ferrari); its Chairman is Nitin Nohria (Executive Chairman of Thrive Capital and former Dean of Harvard Business School). Lingotto’s Chairman is George Osborne, former UK chancellor.