Zetta Venture Partners

Zetta Venture Partners is an early-stage venture capital firm founded in 2013 that invests in AI-native companies. The firm was among the first venture practices focused exclusively on AI-driven B2B businesses, and its current mandate concentrates on pre-seed and seed-stage investments in technical founders applying artificial intelligence to science and building tools for scientific discovery.

The firm provides day-zero capital alongside hands-on operational support, with the stated objective of helping founders turn machine-learning models into market-leading companies. Its technical domain coverage spans artificial intelligence, machine learning and applied AI, biotechnology, climate technology, DevOps, cloud infrastructure, security and B2B software.

Zetta lists 32 portfolio companies and maintains offices in San Francisco and New York City. The team is drawn from investing, operations, product, policy and engineering backgrounds. A dedicated portfolio careers site lists open roles across the firm's companies, making it a route into early-stage AI and frontier-science businesses beyond investing positions at the firm itself.