Pivotal Life Sciences

Our mission is to serve as a catalyst for innovation by providing early-stage strategic capital and expert guidance to visionary entrepreneurs and researchers. We're committed to propelling revolutionary technologies and treatments poised to transform healthcare and significantly enhance the lives of patients and their families. About Us At Shannon Life Sciences, we are driven by a passion for innovation. We specialize in identifying and supporting early, groundbreaking ideas that have the potential to revolutionize the treatment of patients. Our team is a mosaic of experts in healthcare, finance, and entrepreneurship. This diverse expertise, coupled with a deep understanding of the healthcare sector and the intricacies of bringing novel therapies to market, positions us to help enable our portfolio companies to be successful. Our role extends beyond funding. We actively engage with academic institutions, visionary entrepreneurs, and industry leaders, forging partnerships that propel cutting-edge therapies and technologies into the healthcare arena.

When we founded the firm in 2007, our imaginations were on fire with the possibility of translating scientific discoveries to breakthrough medicines. Could we finally find cures for cancer? Would we be able to diagnose diseases before they even appear? How far could we go in restoring hope and quality of life to patients with incurable conditions? We dared to believe that nothing was impossible. To achieve what hadn’t been done before, we created a process that hadn’t been done before. By starting with big ideas and fostering collaboration among brilliant people with expertise in science, medicine, business and strategy, we set out to do more than fund startups – we aim to build sustainable, innovative companies that can transform the lives of patients. Discover Our Discovery effort is a collaborative and iterative process. We look for emerging fields of science and medicine where the time is right for us to bring transformative change to areas of unmet medical need. Working with leading scientific founders and expert advisors, we then develop a clear vision and strategy for a company with the patient front and center. With 12 years and over 50 companies worth of experience, we have created an industry-leading and differentiated approach to bring breakthrough science to patients. Launch Once a company concept has been refined and optimized through our Discovery process, we Launch the company with the necessary financial, technical and human resources to enable it to reach milestones critical for its growth and success. We become active members of the company’s leadership team, serving in interim roles to ensure the execution of the company’s R&D strategy, and to build a world-class team that shares the company’s scientific vision. Importantly, we work to establish a dynamic and innovative culture at launch where the growing team has a unified passion and commitment to make a difference in the lives of patients. Build Next, we Build on that foundation. We transition out of our interim roles and establish experienced and motivated management teams. As board members and domain experts, we work with these teams for as long as is needed to relentlessly execute on the strategy, bringing whatever resources are required from within the firm to deliver on our commitment to patients. An important element is the work we do to cultivate future partnerships and drive value creating transactions. Our companies also have access to our Beyond Great learning community, which provides peer-to-peer networking for leaders across the portfolio as well as tools and resources focused on shared elements of building successful and sustainable companies. Transform Our companies are now bringing products to patients – Transforming their lives, and the lives of their families. Third Rock portfolio companies have now launched 16 products. It is this that we are most proud of, as it means we are delivering on our mission of creating great companies that discover and develop products that make a difference for the patients we serve. Mission & Core Values Third Rock's mission is to be the preferred partner for entrepreneurs, investors, employees and industry to build great companies that discover and develop products that make a difference for the patients we serve. Integrity: always do the right thing Attitude: nothing is impossible Patients: making a difference through breakthroughs in medicine Partners: make them raving fans Organization: great people, great culture, great accomplishments Entrepreneurs: passionately innovate, found, build, have fun

Luma Group is passionately leading a transformation in healthcare, driven by a deep-seated commitment to enhance human health. We’re on a mission to turn visionary science into revolutionary healthcare solutions. Our team unites a dynamic mix of investors, scientists, clinicians, and entrepreneurs, all dedicated to advancing human health outcomes. We are not just funding remarkable scientific discoveries; we are investing in the future of humanity. Our focus is on nurturing groundbreaking innovations leveraging advanced computation and artificial intelligence that promise to redefine healthcare, ensuring that every investment we make contributes to a healthier, brighter future for all. Our approach is hands-on and collaborative, partnering with the brightest minds in science, clinical research, engineering, and entrepreneurship. We’re not just investors; we’re co-creators, working side-by-side with innovators and dreamers to transform cutting-edge scientific discoveries into groundbreaking therapeutics, diagnostics, and medical devices. Our goal is clear: to make a significant and lasting impact on human health. Every project we embark on is a step towards redefining what’s possible in healthcare, ensuring that we’re not just part of the conversation, but leading the charge in creating a healthier future for everyone.

Cambrian Biopharma, a multi-asset longevity biotech, is building the medicines that will redefine healthcare in the 21st century – therapeutics to lengthen healthspan, the period of life spent in good health. By partnering with leading academic institutions and biotech entrepreneurs all over the world, we are advancing a diversified pipeline of novel therapeutics, each targeting a biological driver of aging. Our approach is to develop interventions that treat specific diseases first, then deploy them as preventative medicines to improve overall quality of life as we age. Cambrian is a Distributed Development Company (or DisCo) which combines the advantages of a venture capital firm and a big pharmaceutical company, with the nimbleness of a biotech startup. Cambrian’s sourcing and development engine allows us to identify promising science, deploy capital and teams of drug development experts, and provide stewardship to advance new medicines. By leveraging established expertise and repeatable functional models, we achieve vast efficiencies in execution speed and resource utilization. To date, we have 14 novel therapeutics in development, and having closed a Series C financing round in October 2021 which raised $100 million, we plan to expand the number of programs. Further, we expect to initiate clinical trials for three programs in the next 18 months.

Cure Ventures harnesses its team's skills and decades of company-building experience to create innovative companies that aim to eradicate diseases by focusing on de novo company formation built around bold ideas and visionary entrepreneurs. Cure Ventures will provide the right level of human and financial capital that is required at each stage of the company's life. We seek to build great companies around pioneering scientific solutions with strong intellectual property positions. The Cure Ventures team intends to focus on disruptive technologies that target high unmet patient needs. The optimal company build will exhibit a clear genetic validation, substantiated and rigorously derived scientific data. the provenance of a distinguished scientific laboratory, biology with mechanistic clarity, multiple commercial applications, large uncrowded markets, expedited clinical routes, string partnering interest from large pharmaceutical companies, and an articulable oath to an exit.

We power progress that advances healthcare innovation, uplifts communities, and improves lives. For close to 60 years, the Science Center has been at the forefront of innovation in science and technology that elevates our region and enriches our world. Along the way, we've proven that you can accomplish amazing things when you bring the right people together in the right place at the right time, and we take pride in creating those connections every day. We are a community of current and future innovators, makers and doers fueling billions into the economy, expanding the workforce, and solving problems to enable us to live longer and better. We offer a broad array of places and programs that enable new ideas to blossom and new businesses to thrive.