Investment Principal, Therapeutics

About Mubadala Capital

Mubadala Capital is a global alternative asset management platform that manages, advises, and administers over $755 billion in assets for clients and limited partners through its core alternatives businesses and strategic partnerships. As a subsidiary of Mubadala Investment Company, Mubadala Capital combines the scale and stability of sovereign ownership with the agility and focus of a performance-driven global alternative asset management firm.

Mubadala Capital's core alternatives businesses manage and invest over $60 billion in assets across private equity, special opportunities with a focus on Brazil, credit, and venture capital, as well as Solutions and co-investment platforms. Additionally, Mubadala Capital maintains a portfolio of strategic businesses and partnerships in private wealth, public credit, insurance, and real estate, among other areas.

Mubadala Capital’s values—ambitious, responsible, resilient, and respectful—define not only how the firm invests, but also how we operate and make decisions every day. From how we lead to how we hire, these values reflect a commitment to excellence, integrity, and partnership, and serve as the foundation for the firm’s global culture and long-term success.

With more than 250 professionals across offices in Abu Dhabi, London, New York, Rio de Janeiro, and San Francisco, Mubadala Capital serves as a partner of choice to institutional and private investors seeking differentiated risk-adjusted returns across private markets.

For more information, visit our website at www.mubadalacapital.ae or find us on LinkedIn.

Position Overview

The Investment Principal will play a key role in advancing Mubadala Capital Ventures’ therapeutics investing effort. The Ventures team backs exceptional founders building transformative businesses, and its healthcare practice has invested in over 50 companies across biopharma, HealthTech, and healthcare services. The therapeutics practice focuses on novel medicines and platform technologies across drug discovery and development, partnering with founders from formation through clinical proof of concept and beyond, and backing programs grounded in differentiated biology with clear paths to addressing unmet medical needs.

Reporting to Mubadala Capital’s Healthcare Investment Team Leadership, the Investment Principal will develop investment theses, source and evaluate opportunities, lead and support due diligence and financial underwriting, and contribute to the ongoing management of portfolio investments. The role combines strong scientific and drug development expertise with clinical judgment and institutional investment discipline. This position offers a meaningful opportunity to play a leading role in sourcing, evaluating, and executing new investment opportunities, while further strengthening and scaling the therapeutics investment platform within the Ventures team.

Key Responsibilities

Developing Investment Theses and Supporting New Investments

• Lead development of investment theses and priority areas, drawing on scientific deep dives, competitive landscaping, and target identification.
• Translate investment theses into prioritized company and program maps and actionable sourcing strategies.
• Originate high-quality opportunities through scientific, academic, clinical, founder, and investor networks, as well as targeted outbound sourcing and inbound screening.
• Support and lead scientific, clinical, commercial, and financial diligence, including expert engagement, assessment of preclinical and clinical data, and valuation, returns, and scenario analysis.
• Support and linvestment processes from diligence through execution, including drafting investment memoranda and Investment Committee materials and coordinating internal and external workstreams.

Portfolio Management and Support

• Build strong relationships with portfolio company management teams and engage on key scientific, clinical, financing, and strategic priorities.
• Monitor portfolio investments against underwriting, including scientific and clinical milestones, financing needs, follow-on rounds, key risks, and potential exit paths.
• Contribute to quarterly and semi-annual portfolio reviews and related internal reporting.
• Represent the firm, where applicable, on portfolio company boards or as a board observer.

Platform Development

• Maintain a strong network across the therapeutics and life sciences ecosystem to support sourcing, diligence, and market intelligence.
• Represent Mubadala Capital at relevant scientific and industry conferences, events, and workshops.
• Develop thematic research and thought leadership to inform investment strategy and identify emerging areas of opportunity.
• Support and mentor junior team members, helping to develop their scientific and investment judgement.
• Strengthen the therapeutics investment platform through improved sourcing infrastructure, diligence and underwriting frameworks, scientific advisory networks, portfolio monitoring, knowledge management, and reporting processes.

Qualifications & Experience

• 8+ years of relevant therapeutics, life sciences, and investment experience.
• Experience across venture capital, growth equity, or private equity with a focus on therapeutics or life sciences. Candidates with equivalent experience in drug development, translational research, clinical practice, or biopharma operating roles, complemented by direct exposure to investing, will also be considered.
• PhD, MD, or equivalent advanced degree in a scientific or medical field, with deep scientific, drug development, or clinical expertise; an additional MBA or MS is preferred but not required.
• Track record of contributing to investments across the life cycle, from sourcing and thesis development through due diligence, underwriting, execution, and portfolio monitoring, with the ability to lead complex workstreams and support investment decision-making.
• Deep understanding of the therapeutics landscape, including drug discovery and development, the clinical trial process, and key considerations across therapeutic areas.
• Working knowledge of the regulatory and clinical development environment relevant to therapeutics, including the FDA approval pathway.
• Strong understanding of the investment process, including the ability to lead due diligence, valuation, financial underwriting, and Investment Committee preparation, and to translate scientific and clinical insights into sound investment judgement.
• Strong research and analytical skills, including advanced financial analysis, valuation, and modeling capabilities.
• Willingness to support and mentor junior team members.
• Excellent written communication and presentation skills.
• Highly organized and diligent about documentation.

Mubadala Capital is proud to be an equal opportunities employer. We are committed to providing an inclusive environment for our colleagues and recognize the important role that diversity of talent plays in the workplace. All applicants are welcome and will be given equal consideration, without attention to race, religion or belief, sex, sexual orientation, gender, disability, marriage and civil partnership, pregnancy and maternity, or age.