A100x Ventures

A100x Ventures is a New York-based venture capital firm that invests at pre-seed and seed in founders building at the intersection of artificial intelligence and blockchain. Its stated technical scope spans digital assets, blockchain infrastructure, web3, decentralized finance, digital identity, enterprise infrastructure, and middleware and application development. In May 2025 the firm announced A100x Ventures Fund II, a second vehicle with $50 million in commitments dedicated to early-stage companies developing applications and middleware that integrate AI and blockchain.

Sector emphasis within that thesis concentrates on decentralized finance, digital identity, enterprise infrastructure, and applied artificial intelligence, with a stated focus on practical, real-world use cases and on driving adoption of these technologies among enterprises and consumers. The approach is described as thesis-driven, and the firm positions its involvement as extending beyond capital to support founders directly.

The partnership is managed by Nisa Amoils and Sal Ternullo, whose backgrounds span venture investing, law, financial services, and web3. A100x Ventures operates from New York, United States.